Question Answer What is malignant hyperthermia hypermetabolic disorder of the skeletal muscle what is it triggered by succinylcholine and inhalation agents (sevo, des, iso, halothane, enflurane) most common population < 15 years old (all ethnic groups) genetics autosomal dominant gentics show its strongest link to the _____ ryandine receptor (RYR1) symptoms all your muscles are lit up – so expect to see: tachycardia and/or arrhythmias, increased O2 consumption, increased CO2, increased heat production, lactic acid production, ATP depletion, myoglobinuria, renal failure what would increase in the blood acidosis, potassium, myoglobin, CK always associated with what? volatile anesthetic – with or without succs summarization of clinical picture increased intracellular calcium + increased body metabolism clinical picture sudden increase in ETCO2, tachycardia, tachypnea, labile BP, muscle rigidity (masseter), increased temp, dark urine, mottled skin, drop in SaO2 lab findings mixed resp/metabolic acidosis on ABG, elevated K, elevated CK, elevated serum myoglobin, elevated urine myoglobin diseases linked to MH Central core disease, king denborough syndrome, duchenne or becker muscular dystrophy, neuroleptic malignant syndrome, myotonia congenita, myotonic dystrophy what monitors standard What are some things that can be done for someone suspected of having MH prophylactic underbody cooling blanket, MH cart nearby stocked (with un-expired meds), remove triggering agents from work area, ***flush anesthesia machine w/ >10L for 20-104 minutes, ***charcoal filters on insp/exp limbs, communicate with everyone risks What are you going to do post-event? ICU admit for at least 36 hrs, dantrolene post-crisis for 24 hrs, ***awareness of potential crisis recurrence – happens 25% of the time
Pathophysiology Test 2: Malignant hyperthermia

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